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Avastin

Genentech, Inc.

Avastin (bevacizumab) injection is a vascular endothelial growth factor directed antibody indicated for the treatment of metastatic colorectal cancer and metastatic colorectal cancer and used off-label to treat age-related macular degeneration (AMD).

At-a-Glance

Mechanism of Action: Bevacizumab binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells. The interaction of VEGF with its receptors leads to endothelial cell proliferation and new blood vessel formation in in vitro models of angiogenesis.

Details

FDA

Yes (not for ophthalmic use)

CE Mark

Not specified

Active Ingredients

Bevacizumab

Application

Intravitreal

Status

Prescription

Strength

Not specified

Company Information

Contact the company for additional information, availability, or pricing:

Genentech, Inc.

www.gene.com

1 DNA Way

South San Franciso, CA 94080